InVivoMAb anti-mouse/ human/rat/monkey ICOS (CD278)
Cat.#
BE0353
规格
1mg
The C398.4A monoclonal antibody reacts with mouse, human, rat and monkey ICOS (inducible T cell co-stimulator), also known as CD278. ICOS is a 47-57 kDa homodimeric glycoprotein belonging to the CD28 family of costimulatory molecules. ICOS is expressed on activated T cells and upon ICOSL binding, co-stimulates T and B cell responses. The ligand Is expressed on antigen presenting cells including splenic B cells, dendritic cells, and macrophages. ICOS signaling is also thought to be important for maintaining regulatory T cell homeostasis. The C398.4A antibody is commonly used to costimulate T cell activation and proliferation in vitro. C398.4A does not block the binding of ICOS to ICOSL.
概述
| Isotype | Armenian hamster IgG |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb polyclonal Armenian hamster IgG |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | Mouse T cell line D10.G4.1 |
| Reported Applications | in vitro T cell stimulation/activation Flow cytometry Immunoprecipitation |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2894772 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
应用
储存
4°C
